Matrix Nutrition Night Shredder Review

Matrix Night Shredder is from UK based company matrix-nutrition.co.uk. The description of this product states that it is a non stimulant with fat burning properties and has sleep promoting properties. This review will aim to examine the ingredients to understand this product can achieve this.

Raspberry Ketone

Raspberry Ketone is derived from the chemical of red raspberries. It has been found to prevent and reduce obesity and fatty liver (1). This is due to raspberry ketone altering lipid metabolism by stimulating lipolysis and fatty acid oxidation (2) and reducing fat mass in adipocytes (3).

L-Carnitine

L-Carnitine is a dipeptide made from the essential amino acids lysine and methionine. L-Carnitine plays an important role in fat metabolism by allowing long chained fatty acids to pass through the mitochondrial membrane (4, 5).

Irvingia Gabonensis

Irvingia Gabonensis is a water soluble dietary fibre (6). It has been found to delay stomach emptying which leads to the gradual absorption of dietary sugar (7). The lowering of cholesterol has also been found to be a key component of this ingredient by binding to bile acids (8).

CLA

Conjugated Linoleic Acid (CLA) has been shown to have weight loss properties (9); there are several reasons for this which includes an increase in energy metabolism (10), insulin resistance (11), stimulation of lipolysis, which is due to an impaired signalling which reduces triglyceride synthesis and releases free fatty acid which normally occurs when energy demand rises (12). Other mechanisms include a suppression of appetite (13), induced adipocyte apoptosis which decreases body fat mass and increased energy expenditure (14).

Magnesium

Magnesium has been found to be used for 300 biochemical reactions in the body (15). It has been found to maintain muscle function (16), supports a healthy immune system (17), keeps the heart beat steady (18), and helps strengthen bones (19). It has also been found to maintain blood glucose levels (20) and aid in the production of energy and protein.

Theanine

Theanine is an amino acid that is found in green tea. Green tea supplementation has been shown to have several health properties including an increase in plasma antioxidant which will lead to a lowering of oxidative damage (21, 22), decreased blood pressure (23, 24) and it can protect against coronary atherosclerosis (25). Other health effects that green tea can have includes a lowering of cholesterol, an increase of insulin activity (26) and a regulation of blood glucose levels which can help reduce body fat.

5-HTP

5-HTP has been known to produce significant effects on food intake in obese populations; research has found that this is done by increasing serotonin which will help avoid food craving, post meal satiety and reduction of pre meal appetite. (27)

Gelatine

Gelatine is a protein which is made from amino acids glycine and proline. The suggested benefits of gelatin have been to boost metabolism and increase satiety, however there is insufficient evidence to reinforce these claims.

Glycerin

Glycerin is a thick colourless, odourless liquid which has been suggested to be a hyper hydrating agent (28). The main reason for this is that it can increase blood osmolality which augments the retention of water (29). It has been suggested to lower heart rate and prolong exercise (30), however research is still sparse on this ingredient further studies are needed in order to fully understand the capabilities of glycerin.

Purified Water

This ingredients in this product has been found to help aid fat metabolism and has antioxidant properties. It was stated that this product can be taken at night, as it doesn’t contain any stimulants it means that it can be used for this purpose. This product has no banned substances when referring to the WADA prohibited list when observing the label/ ingredients posted on the website.

*NOTE – This product has not been tested in a laboratory and may contain other substances that may not appear on the label

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2 – Park, K. S. (2010). Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta medica, 76(15), 1654.

3 – Kosjek, B., Stampfer, W., van Deursen, R., Faber, K., & Kroutil, W. (2003). Efficient production of raspberry ketone via ‘green’biocatalytic oxidation.Tetrahedron, 59(48), 9517-9521.

4 – Siliprandi, N., Sartorelli, L., Ciman, M., & Di Lisa, F. (1989). Carnitine: metabolism and clinical chemistry. Clinica Chimica Acta, 183(1), 3-11.

5 – Müller, D.M., Seim, H., Kiess, W., Löster, H. & Richter, T. (2002) Effects of Oral l-Carnitine Supplementation on In Vivo Long-Chain Fatty Acid Oxidation in Healthy Adults Metabolism, Volume 51, issue 11, (pp. 1389-1391)

6 – Ngondi, Judith L., Julius E. Oben, and Samuel R. Minka. “The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon.” Lipids Health Dis 4 (2005): 12.

7 – Vuksan, V. L. A. D. I. M. I. R., Jenkins, D. J., Spadafora, P., Sievenpiper, J. L., Owen, R. O. B. I. N., Vidgen, E. D. W. A. R. D., … & Bruce-Thompson, C. H. A. R. L. E. S. (1999). Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. Diabetes Care, 22(6), 913-919.

8 – Arvill, A., & Bodin, L. (1995). Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. The American journal of clinical nutrition, 61(3), 585-589.

9 – Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., Wadstein, J., & Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of nutrition, 130(12), 2943-2948.

10 – House, R. L., Cassady, J. P., Eisen, E. J., McIntosh, M. K., & Odle, J. (2005). Conjugated linoleic acid evokes de‐lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue. obesity reviews, 6(3), 247-258.

11 – Chung, S., Brown, J. M., Provo, J. N., Hopkins, R., & McIntosh, M. K. (2005). Conjugated linoleic acid promotes human adipocyte insulin resistance through NFκB-dependent cytokine production. Journal of Biological Chemistry, 280(46), 38445-38456.

12 – Evans, M., Lin, X., Odle, J., & McIntosh, M. (2002). Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. The Journal of nutrition, 132(3), 450-455.

13 – Medina, E. A., Horn, W. F., Keim, N. L., Havel, P. J., Benito, P., Kelley, D. S., … & Erickson, K. L. (2000). Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite. Lipids, 35(7), 783-788.

14 – Zambell, K. L., Keim, N. L., Van Loan, M. D., Gale, B., Benito, P., Kelley, D. S., & Nelson, G. J. (2000). Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids, 35(7), 777-782.

15 – Ryan, M. F. (1991). The role of magnesium in clinical biochemistry: an overview.Annals of Clinical Biochemistry: An international journal of biochemistry in medicine, 28(1), 19-26.

16 – Dørup, I., Skajaa, K., Clausen, T., & Kjeldsen, K. (1988). Reduced concentrations of potassium, magnesium, and sodium-potassium pumps in human skeletal muscle during treatment with diuretics. British medical journal (Clinical research ed.), 296(6620), 455.

17 – Tam, M., Gomez, S., Gonzalez-Gross, M., & Marcos, A. (2003). Possible roles of magnesium on the immune system. European journal of clinical nutrition,57(10), 1193-1197.

18 – White, R. E., & Hartzell, H. C. (1989). Magnesium ions in cardiac function: regulator of ion channels and second messengers. Biochemical pharmacology,38(6), 859-867.

19 – Okuma, T. (2001). Magnesium and bone strength. Nutrition, 17(7), 679-680.

20 – Paolisso, G., Scheen, A., d’Onofrio, F., & Lefèbvre, P. (1990). Magnesium and glucose homeostasis. Diabetologia, 33(9), 511-514.

21- Rietveld, A., & Wiseman, S. (2003). Antioxidant effects of tea: evidence from human clinical trials. The Journal of nutrition, 133(10), 3285S-3292S.

22 – McKay, D. L., & Blumberg, J. B. (2002). The role of tea in human health: an update. Journal of the American College of Nutrition, 21(1), 1-13.

23 – Yang, Y. C., Lu, F. H., Wu, J. S., Wu, C. H., & Chang, C. J. (2004). The protective effect of habitual tea consumption on hypertension. Archives of internal medicine, 164(14), 1534-1540.

24 – Hodgson, J. M., Devine, A., Puddey, I. B., Chan, S. Y., Beilin, L. J., & Prince, R. L. (2003). Tea intake is inversely related to blood pressure in older women. The Journal of nutrition, 133(9), 2883-2886.

25 – Sasazuki, S., Kodama, H., Yoshimasu, K., Liu, Y., Washio, M., Tanaka, K., … & Takeshita, A. (2000). Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women. Annals of epidemiology, 10(6), 401-408.

26 – Anderson, R. A., & Polansky, M. M. (2002). Tea enhances insulin activity. Journal of Agricultural and Food Chemistry, 50(24), 7182-7186.

27 – Halford, J. C., Harrold, J. A., Lawton, C. L., & Blundell, J. E. (2005). Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Current drug targets, 6(2), 201-213.

28 –  WAGNER, D. (1999). Hyperhydrating with glycerol: implications for athletic performance. Journal of the American Dietetic Association, 99(2), 207-212.

29 – Robergs, R. A., & Griffin, S. E. (1998). Glycerol. Sports Medicine, 26(3), 145-167.

30 – Montner, P., Stark, D. M., Riedesel, M. L., Murata, G., Robergs, R., Timms, M., & Chick, T. W. (1996). Pre-exercise glycerol hydration improves cycling endurance time. International Journal of Sports Medicine, 17(01), 27-33.